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KMID : 0370220070510040277
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Yakhak Hoeji
2007 Volume.51 No. 4 p.277 ~ p.284
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Hepatoprotective Effects of the Water Extract of Protaetia brevitarsis Larva Against Carbon Tetrachloride-Induced Liver Injury in Rats
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Yoon Soo-Hong
Kim Duk-Hyun
Lee Sang-Kyu
Kim Ju-Hyun
Seo Young-Min
Kang Mi-Jeong
Jeon Tae-Won
Jeong Tae-Cheon
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Abstract
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Hepatoprotective effects of the water extract of Protaetia brevitarsis larva (PB) was investigated in carbon tetrachloride ($CCI_{4}$) treated male Sprague-Dawley rats. PB administration protected rats against ALT, AST and LDH elevations induced by $CCI_{4}$, as well as the severity of liver damage. PB recovered the decrease in serum level of high-density lipoprotein-cholesterol and the increase in serum level of low-density lipoprotein-cholesterol induced by $CCI_{4}$. In histopathological observation, massive fatty change and necrosis in the centrilobular area, degenerative change including pyknosis of nucleus and swelling of parenchymal cell induced by $CCI_{4}$ were clearly protected by PB. These histopathological findings paralleled with the serum biochemical results. The present results demonstrated that the water extract of PB may have the hepatoprotective effect against $CCI_{4}$-induced liver damage in vivo
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KEYWORD
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hepatoprotective effect, Protaetia brevitarsis larva, carbon tetrachloride
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